题    目：Mathematical modeling on T cell homeostatic proliferation in HIV infection and persistence

主讲人：董岳平 副教授

单    位：华中师范大学

时    间：2025年11月7日 15:30

地    点：数学院二楼会议室

摘    要：Recent clinical studies have displayed that the homeostatic proliferation of CD4+ T cell is one of the major drivers of HIV infection and persistence, since the replenishment of target T cells offers more chance of being infected with free HIV viruses. We propose and study several HIV infection models with the CD4+ T homeostatic proliferation, which can induce very rich dynamics, such as saddle-node bifurcations, supercritical and subcritical Hopf bifurcations, saddle node bifurcations related to periodic orbits, and Bogdanov Takens bifurcations and so on. Besides, we fit the dynamical model to clinical data on long-term CD4+ T cell counts before and after treatment. Our findings emphasize the critical role of CD4+ T cell homeostatic proliferation in HIV infection and persistence despite treatment, providing valuable insights for understanding disease progression and developing more effective therapies, potentially towards eradication.

简    介：董岳平，华中师范大学副教授，博士生导师。中国数学会生物数学专委会青年委员、中国工业与应用数学会数学生命科学专委会委员。于2014年获得日本静冈大学理学博士、曾在日本东京大学医学院任全职博土后。主要从事生物数学、微分方程和动力系统理论及其在生命医学中的应用研究等。近年来在SIAM J. Appl. Math.、SIAM J. Appl. Dyn. Syst.、Nonlinearity、Am. Nat.、Infect. Dis. Model.、J. Math. Biol.、J. Theor. Biol.、BMJ Open等国际知名SCI期刊上发表学术论文30余篇。先后主持国家自然科学基金项目2项、以及湖北省自然科学基金项目等科研项目6项。